Development of a reliable method for measuring electrical properties of biological cells

Precise positioning of cells is a necessary component for successful utilization of certain classes of BioMEMS (micro-electro-mechanical system) devices.  In our lab, we use dielectrophoresis (DEP) to trap cells in desired positions within BioMEMS.  Our work has shown that different ranges of parameters are specific for sucessful trapping of different types of cells. However, these parameters are not often obvious, and conditions for cell capture must be empirically determined.  It has been suggested, however, that the dielectric properties of individual cell types can be used to anticipate the parameters necessary for successful cell trapping by dielectrophoresis.

 

The focus of our project, therefore, will be to continue our efforts to implement an experimental setup, designed by 2009 BDSI students, for measuring the dielectric properties of mammalian cells. The information obtained will be used to model the optimal range of parameters to be used for cell trapping by dielectrophoresis for use in a BioMEMS device, and will aid in the successful design of DEP electrodes. 

 

Our interdisciplinary project is a collaborative effort between Svetlana Tatic-Lucic (Electrical and Computer Engineering and Bioengineering) and Susan Perry (Bioengineering)